Description

Piperazinone, 3-(Phenylmethyl)-, (S)- (9Ci) CAS NO 134676-49-6 is a high-purity, single-enantiomer chiral building block of significant interest in advanced organic synthesis. This compound matters because its specific stereochemistry and functional groups make it a critical intermediate for constructing complex, biologically active molecules with precise three-dimensional structures. Pharmaceutical research and development teams need it for the synthesis of potential new drug candidates, particularly in areas requiring high stereochemical purity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and metabolic disorder targets.
• Asymmetric Synthesis: Used as a building block in stereoselective reactions to introduce the (S)-configured piperazinone core into more complex molecular architectures.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities with therapeutic potential.
• Peptidomimetic Development: Serves as a constrained scaffold in the design of peptidomimetics, which are molecules that mimic peptides but with improved stability and bioavailability.
• Chemical Biology Probes: Utilized in the synthesis of specialized probes for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for client R&D programs.

Basic Information

Product Name	Piperazinone, 3-(Phenylmethyl)-, (S)- (9Ci)
CAS No.	134676-49-6
Molecular Formula	C11H14N2O
Molecular Weight	190.24 g/mol
Synonyms	(S)-3-Benzylpiperazin-2-one; (S)-3-Benzyl-2-piperazinone; (3S)-3-Benzylpiperazin-2-one; (S)-3-Benzyl-1,4-diazinan-2-one; 3-Benzyl-2-piperazinone, (S)-; L-3-Benzyl-2-piperazinone; (S)-(-)-3-Benzyl-2-piperazinone; 134676-49-6
EINECS	Contact for details

Quality Control

Our Piperazinone, 3-(Phenylmethyl)-, (S)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.