Description

(R)-2-Formyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-value, chiral piperidine derivative that serves as a critical building block in advanced organic synthesis. Its primary value lies in its role as a key chiral intermediate for the preparation of complex pharmaceutical molecules, particularly those targeting the central nervous system. This compound is essential for medicinal chemistry researchers and process development chemists in the pharmaceutical and agrochemical industries who require enantiomerically pure intermediates for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of neurological and psychiatric drugs.
• Asymmetric Synthesis: Used as a chiral auxiliary or precursor in asymmetric catalytic reactions to introduce stereogenic centers into complex molecules.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and commercial route development for chiral drugs.
• Agrochemical Synthesis: Potential use in the creation of enantiomerically pure pesticides and herbicides.
• Academic Research: A valuable reagent for methodology development in organic chemistry and total synthesis of natural products.

Basic Information

Product Name	(R)-2-Formyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	134526-69-5
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	(R)-1-Boc-2-formylpiperidine; (R)-N-Boc-2-formylpiperidine; (R)-2-Formyl-1-(tert-butoxycarbonyl)piperidine; (R)-1-(tert-Butoxycarbonyl)-2-formylpiperidine; (R)-tert-Butyl 2-formylpiperidine-1-carboxylate; (R)-N-Boc-piperidine-2-carboxaldehyde; (R)-Piperidine-2-carboxaldehyde, 1-(1,1-dimethylethyl) ester; (R)-2-Formylpiperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (R)-2-Formyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure high chemical and chiral purity, which is critical for sensitive pharmaceutical applications. Each batch is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC, GC, and NMR, to confirm identity, purity, and enantiomeric excess (ee). Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.