Description

2,5-Piperazinedione,3-Phenyl-,(3S)-(9Ci) CAS NO 134521-82-7 is a chiral, non-proteinogenic piperazinedione derivative, a key structural motif in medicinal chemistry. This high-purity chiral building block is essential for the synthesis of complex molecules where stereochemical control is critical. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptidomimetics, and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.
• Peptidomimetic Scaffold: Serves as a constrained dipeptide analog for designing enzyme inhibitors and receptor modulators with enhanced metabolic stability.
• Asymmetric Synthesis: Used as a starting material or auxiliary in stereoselective synthesis to introduce the (S)-phenylglycine moiety into target molecules.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the development of molecular probes.
• Fine Chemical Production: Integral in the multi-step synthesis of advanced, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	2,5-Piperazinedione,3-Phenyl-,(3S)-(9Ci)
CAS No.	134521-82-7
Molecular Formula	C10H10N2O2
Molecular Weight	190.20 g/mol
Synonyms	(3S)-3-Phenylpiperazine-2,5-dione; (S)-3-Phenyl-2,5-piperazinedione; (S)-3-Phenylpiperazine-2,5-dione; L-3-Phenyl-2,5-diketopiperazine; (S)-3-Phenyl-DKP; 3-Phenyl-2,5-diketopiperazine (S-enantiomer); (S)-3-Phenyl-2,5-dioxopiperazine; (S)-3-Phenyl-2,5-piperazinedione (9CI)
EINECS	Contact for details

Quality Control

Our 2,5-Piperazinedione,3-Phenyl-,(3S)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and fine chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.