Description

5-Trifluoromethyl-Pyrazin-2-Ol is a high-purity fluorinated pyrazine derivative, a key heterocyclic building block prized for its unique electronic and steric properties. This compound is essential for introducing the metabolically stable and lipophilic trifluoromethyl group into complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3 group enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for functionalized ligands and organic electronic materials due to its electron-deficient aromatic system.
• Chemical Biology & Probe Development: Employed in the design of biochemical probes and labeled compounds for studying biological mechanisms.
• Custom Synthesis & Contract Manufacturing: A starting material for bespoke chemical synthesis services catering to R&D and pilot-scale production.

Basic Information

Product Name	5-Trifluoromethyl-Pyrazin-2-Ol
CAS No.	134510-03-5
Molecular Formula	C5H3F3N2O
Molecular Weight	164.09 g/mol
Synonyms	2-Hydroxy-5-(trifluoromethyl)pyrazine; 5-(Trifluoromethyl)-2(1H)-pyrazinone; 5-(Trifluoromethyl)pyrazin-2-ol; 2-Pyrazinol, 5-(trifluoromethyl)-; 5-Trifluoromethyl-2-hydroxypyrazine; 5-Trifluoromethyl-2-pyrazinol
EINECS	Contact for details

Quality Control

Every batch of 5-Trifluoromethyl-Pyrazin-2-Ol is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.