Description

1,25-Dihydroxy-26,27-Dihomo-22-Ene-Vitamin D3 is a high-purity, synthetic vitamin D analog designed for advanced research and pharmaceutical development. This compound is critical for studying the nuanced biological pathways of vitamin D receptor (VDR) activation and metabolism. It serves as a key intermediate and reference standard for researchers and manufacturers in the life sciences, pharmaceutical, and nutraceutical industries.

Application

• Pharmaceutical Research & Development: As a reference standard and active pharmaceutical ingredient (API) intermediate for novel therapeutics targeting bone metabolism, immune modulation, and cell differentiation.
• Biochemical Research: A critical tool for in vitro and in vivo studies investigating the structure-activity relationships (SAR) of vitamin D analogs and their interaction with the VDR.
• Metabolic Pathway Analysis: Used to elucidate specific enzymatic pathways involved in the synthesis and degradation of vitamin D compounds.
• Analytical Standard: Serves as a high-purity calibration standard for analytical methods such as HPLC, LC-MS, and NMR in quality control laboratories.
• Nutraceutical Development: Investigated for potential applications in advanced dietary supplements targeting specific health conditions.

Basic Information

Product Name	1,25-Dihydroxy-26,27-Dihomo-22-Ene-Vitamin D3
CAS No.	134508-36-4
Molecular Formula	C₂₉H₄₄O₃
Molecular Weight	440.66 g/mol
Synonyms	1,25-Dihydroxy-26,27-dihomo-22-ene-cholecalciferol; 22-Dehydro-1α,25-dihydroxy-26,27-dihomovitamin D₃; 1α,25-Dihydroxy-26,27-dihomo-22-ene-vitamin D₃; 26,27-Dinor-1,25-dihydroxyvitamin D₃ 22-ene analog; EB 1089 analog; Leo Pharmaceutical analog; Vitamin D analog EB 1089 derivative
EINECS	Contact for details

Quality Control

Our 1,25-Dihydroxy-26,27-Dihomo-22-Ene-Vitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at controlled room temperature (15-25°C) or as specified on the label or COA. This product is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.