Description

tert-Butyl 4-Mercaptopiperidine-1-Carboxylate is a high-value, protected piperidine derivative featuring a reactive thiol group, making it a critical building block in advanced organic synthesis. Its primary value lies in its role as a versatile intermediate for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on active pharmaceutical ingredients (APIs), especially in the areas of central nervous system (CNS) drugs and protease inhibitors.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in neurological and antiviral therapeutic areas.
• Peptidomimetic Chemistry: Used to introduce constrained, sulfur-containing piperidine scaffolds into peptide backbones to modulate bioavailability and activity.
• Ligand Synthesis for Catalysis: Serves as a precursor for chiral ligands and catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the development of activity-based probes and bioconjugation reagents due to the reactive thiol moiety.
• Agrochemical Research: An intermediate in the development of new crop protection agents and pesticides.
• Material Science: Potential building block for functionalized polymers and advanced materials.

Basic Information

Product Name	tert-Butyl 4-Mercaptopiperidine-1-Carboxylate
CAS No.	134464-79-2
Molecular Formula	C10H19NO2S
Molecular Weight	217.33 g/mol
Synonyms	1-Boc-4-mercaptopiperidine; 4-Mercapto-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-sulfanylpiperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-mercaptopiperidine; 4-Thiol-1-Boc-piperidine; Boc-4-mercaptopiperidine; N-Boc-4-mercaptopiperidine; 1-N-Boc-4-mercaptopiperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Mercaptopiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We can supply material compliant with cGMP standards for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation of the thiol group and ensure long-term stability. Keep the container in a cool, dry, and well-ventilated place, away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.