Description

tert-Butyl 2,5-Diazabicyclo[2.2.1]heptane-2-carboxylate hydrochloride is a high-purity, pharmaceutically relevant building block and chiral intermediate. This compound is of significant value for its role in constructing complex nitrogen-containing heterocycles, which are core scaffolds in modern medicinal chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile building block for constructing diazabicyclic and bridged heterocyclic systems in drug discovery programs.
• Ligand Synthesis: Serves as a precursor for chiral ligands used in asymmetric catalysis and organometallic chemistry.
• Protease Inhibitor Development: Found in the synthetic pathways of inhibitors targeting various proteases due to its diazabicyclic structure.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying enzyme function and biological pathways.
• Scale-up & Process Chemistry: Supplied for route scouting, optimization, and cGMP manufacturing of clinical trial materials.

Basic Information

Product Name	tert-Butyl 2,5-Diazabicyclo[2.2.1]heptane-2-carboxylate hydrochloride
CAS No.	134003-84-2
Molecular Formula	C11H21ClN2O2
Molecular Weight	248.75 g/mol
Synonyms	2,5-Diazabicyclo[2.2.1]heptane-2-carboxylic acid, 1,1-dimethylethyl ester, hydrochloride; tert-Butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate HCl; 2-(tert-Butoxycarbonyl)-2,5-diazabicyclo[2.2.1]heptane hydrochloride; Boc-2,5-diazabicyclo[2.2.1]heptane hydrochloride; (1R,4S)-tert-Butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate hydrochloride (for enantiopure form); 2,5-DABCO derivative hydrochloride; Bicyclic Diamine Boc-protected Hydrochloride Salt
EINECS	Contact for details

Quality Control

Our tert-Butyl 2,5-Diazabicyclo[2.2.1]heptane-2-carboxylate hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, chiral HPLC) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (for enantiopure grade)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.