Description

Hydroxy-Peg3-T-Butylester is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal hydroxyl group and a tert-butyl ester-protected carboxylic acid. This bifunctional structure makes it a versatile and valuable building block for the synthesis of complex molecules, enabling precise control over solubility, conjugation, and linker length. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for developing drug delivery systems, diagnostic agents, and functional polymers.

Application

• Pharmaceutical Intermediates: A key building block for synthesizing prodrugs, antibody-drug conjugates (ADCs), and targeted therapeutic agents.
• Bioconjugation & Linker Chemistry: Used to create hydrophilic spacers or linkers for attaching drugs, dyes, or targeting moieties to proteins, peptides, or nanoparticles.
• Polymer & Material Science: Serves as a functional monomer or cross-linker for creating PEGylated hydrogels, smart materials, and surface coatings with enhanced biocompatibility.
• Prodrug Synthesis: The tert-butyl ester protecting group allows for controlled release of active carboxylic acid drugs under specific physiological conditions.
• Diagnostic Reagent Development: Employed in the fabrication of contrast agents and fluorescent probes for imaging applications.
• Chemical Biology Research: A valuable tool for modifying biomolecules to study their function, interaction, and localization.

Basic Information

Product Name	Hydroxy-Peg3-T-Butylester
CAS No.	133803-81-3
Molecular Formula	C15H30O7
Molecular Weight	322.40 g/mol
Synonyms	3,6,9-Trioxaundecanedioic acid, 11-hydroxy-, 1-(1,1-dimethylethyl) ester; 11-Hydroxy-3,6,9-trioxaundecanedioic acid tert-butyl ester; tert-Butyl 11-hydroxy-3,6,9-trioxaundecanoate; HO-PEG3-t-butyl ester; 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]acetic acid tert-butyl ester; Hydroxy-PEG3-acid t-butyl ester; PEG3-acid t-butyl ester, hydroxyl terminated
EINECS	Contact for details

Quality Control

Our Hydroxy-Peg3-T-Butylester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your research and cGMP-compliant manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. The product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.