Description

Piperazine-2-Carboxylic Acid CAS NO 133525-05-0 is a high-purity, non-proteinogenic amino acid derivative featuring a piperazine ring, a crucial heterocyclic scaffold in medicinal chemistry. This compound serves as a versatile and valuable chiral building block for the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing novel compounds with potential therapeutic and biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of protease inhibitors, kinase inhibitors, and other small molecule drugs.
• Peptidomimetics Research: Used to incorporate constrained, heterocyclic structures into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand Synthesis for Catalysis: Serves as a precursor for creating chiral ligands used in asymmetric synthesis and metal-catalyzed reactions.
• Agrochemical Development: Employed in the research and synthesis of novel herbicides, fungicides, and plant growth regulators.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring high-purity, specialized heterocyclic compounds.

Basic Information

Product Name	Piperazine-2-Carboxylic Acid
CAS No.	133525-05-0
Molecular Formula	C5H10N2O2
Molecular Weight	130.15 g/mol
Synonyms	D-Pipecolic Acid; (R)-Piperazine-2-carboxylic acid; (R)-Piperazine-2-carboxylic acid hydrochloride; 2-Piperazinecarboxylic Acid; D-Pipecolinic Acid; (R)-(-)-Pipecolic Acid; (R)-Piperazine-2-carboxylic Acid Dihydrochloride; Homoproline
EINECS	Contact for details

Quality Control

Our Piperazine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the stringent requirements for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.