Description

Di-(1'-Pyrenemyristoyl)Phosphatidylcholine is a specialized, fluorescently labeled phospholipid derivative, synthesized by conjugating pyrene moieties to the sn-1 and sn-2 positions of a phosphatidylcholine backbone via myristoyl chains. This compound matters as a powerful spectroscopic probe for studying membrane dynamics, lipid-protein interactions, and vesicle fusion kinetics in real-time due to the pyrene group's excimer formation property. It is essential for researchers and formulators in biophysical research, advanced drug delivery system development (particularly liposomes), and diagnostic assay design where precise tracking of lipid behavior is critical.

Application

• Membrane Biophysics Research: As a fluorescent probe for investigating lipid bilayer fluidity, phase transitions, and lateral diffusion using fluorescence spectroscopy and microscopy techniques.
• Liposome & Nanoparticle Tracking: For labeling and real-time monitoring of the stability, fusion, and cellular uptake of engineered liposomal drug carriers and lipid nanoparticles (LNPs).
• Model Membrane Studies: Incorporation into giant unilamellar vesicles (GUVs) or supported lipid bilayers (SLBs) to visualize membrane domain formation and protein binding events.
• Drug Delivery Mechanism Analysis: To study the kinetics of content release and membrane integrity of therapeutic vesicles under various physiological conditions.
• Diagnostic Assay Development: Utilization in fluorescence-based assays for detecting phospholipases, lipid transfer proteins, or other enzymes involved in lipid metabolism.
• High-Throughput Screening (HTS): Serving as a key component in screening platforms for identifying compounds that modulate membrane properties or specific lipid-protein interactions.

Basic Information

Product Name	Di-(1'-Pyrenemyristoyl)Phosphatidylcholine
CAS No.	133304-92-4
Molecular Formula	C78H104NO8P
Molecular Weight	1214.63 g/mol
Synonyms	1,2-Di(1-pyrenedecanoyl)-sn-glycero-3-phosphocholine; 1,2-Bis(1-pyrenedecanoyl)-sn-glycero-3-phosphocholine; Pyrene-PC; DPPyPC; 1,2-Di(1-pyrenoyl)-sn-glycero-3-phosphocholine (common name); Fluorescent phosphatidylcholine; Pyrene-labeled lecithin; 1,2-Di(1-pyrenyl)phosphatidylcholine
EINECS	Contact for details

Quality Control

Every batch of Di-(1'-Pyrenemyristoyl)Phosphatidylcholine is produced and analyzed under strict quality protocols to ensure high purity and consistent performance for sensitive research applications. Our quality assurance includes comprehensive analytical characterization using techniques such as NMR, HPLC, and mass spectrometry to confirm structural integrity and purity. Certificates of Analysis (COA) detailing batch-specific data are provided and available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize degradation. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent exposure to atmospheric moisture. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	Yellow to orange solid or film
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Solubility	Soluble in chloroform, DMSO; sparingly soluble in ethanol
Fluorescence Properties	Excitation ~340 nm, Emission ~376 nm & 470 nm (excimer)
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.