Description

D-Pranoprofen CAS NO 132880-23-0 is the dextrorotatory enantiomer of Pranoprofen, a non-steroidal anti-inflammatory drug (NSAID) belonging to the propionic acid derivative class. This high-purity chiral intermediate is critical for the development of enantiomerically pure pharmaceuticals, offering superior specificity and potentially reduced side-effect profiles compared to racemic mixtures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in advanced drug discovery, process development, and the synthesis of novel anti-inflammatory and analgesic agents.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block for the synthesis of enantiopure active pharmaceutical ingredients (APIs) with anti-inflammatory properties.
• Analgesic Drug Research: Used in preclinical and clinical research for developing new analgesic formulations with improved efficacy and safety margins.
• Chiral Catalyst & Ligand Synthesis: Acts as a precursor for creating specialized chiral catalysts or ligands used in asymmetric synthesis.
• Reference Standard: Employed as a high-purity chemical reference standard in analytical method development and quality control laboratories for HPLC, GC, or LC-MS.
• Biochemical Studies: Utilized in pharmacological studies to investigate the mechanism of action and metabolic pathways of COX enzyme inhibitors.
• Process Chemistry: Integral to scaling up and optimizing manufacturing processes for proprietary NSAID derivatives in GMP environments.

Basic Information

Product Name	D-Pranoprofen
CAS No.	132880-23-0
Molecular Formula	C15H13NO3
Molecular Weight	255.27 g/mol
Synonyms	(+)-Pranoprofen; (R)-Pranoprofen; Dextro-Pranoprofen; (2R)-2-[5H-[1]Benzopyrano[2,3-b]pyridin-7-yl]propanoic acid; D-2-(5H-Chromeno[2,3-b]pyridin-7-yl)propanoic acid; UNII-6Q3S6A6Q4F; (R)-2-(5H-Chromeno[2,3-b]pyridin-7-yl)propionic acid
EINECS	Contact for details

Quality Control

Our D-Pranoprofen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D use. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.