Description

4-Chloro-2,5-Difluorobenzoyl Chloride is a high-purity, multi-functional aromatic acid chloride building block essential for advanced organic synthesis. This compound matters for its role as a key precursor in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its unique halogenated pattern enables precise structural modifications. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel drug candidates, particularly in medicinal chemistry for creating libraries of fluorinated and chlorinated compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoro and chloro substituents enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic materials, contributing to improved performance in display technologies.
• Polymer Chemistry: Employed as a monomer or cross-linking agent for introducing aromatic, halogenated units into high-performance polymers and resins.
• Organic Synthesis Reagent: Functions as a versatile acylating agent in Friedel-Crafts acylation and other reactions to introduce the 4-chloro-2,5-difluorobenzoyl moiety.
• Dye & Pigment Intermediate: Used in the synthesis of specialized halogenated dyes and pigments that require specific light-fastness and color properties.

Basic Information

Product Name	4-Chloro-2,5-Difluorobenzoyl Chloride
CAS No.	132794-08-2
Molecular Formula	C7H2Cl2F2O
Molecular Weight	211.00 g/mol
Synonyms	2,5-Difluoro-4-chlorobenzoyl chloride; 4-Chloro-2,5-difluorobenzoic acid chloride; Benzoyl chloride, 4-chloro-2,5-difluoro-; 4-Chloro-2,5-difluorobenzoic acid chloride; 4-Chloro-2,5-difluorobenzoylchloride; 132794-08-2; 4-Chloro-2,5-difluoro-benzoic acid chloride
EINECS	Contact for details

Quality Control

Our 4-Chloro-2,5-Difluorobenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) to prevent degradation from moisture and ensure maximum shelf life. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	≤ 2.0% total

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.