Description

Rocepafant CAS NO 132418-36-1 is a high-purity, synthetic chemical compound belonging to the class of platelet-activating factor (PAF) receptor antagonists. This compound is of significant interest for its role in advanced pharmacological research and development, particularly in studying inflammatory pathways and related therapeutic interventions. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and reference standards.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and intermediate in the development of novel anti-inflammatory and anti-allergic therapeutics targeting the PAF pathway.
• Biochemical Assay Development: Used as a selective PAF receptor antagonist in in vitro and in vivo studies to elucidate mechanisms of inflammation, anaphylaxis, and bronchoconstriction.
• Academic & Clinical Research: Employed in university and hospital laboratories for fundamental research into cardiovascular diseases, asthma, and immune system modulation.
• Fine Chemical Synthesis: Acts as a key building block or precursor for the custom synthesis of more complex molecules and analogs for structure-activity relationship (SAR) studies.
• GMP Manufacturing Support: Provides a high-quality starting material or reference compound for process development and validation within cGMP environments for API production.

Basic Information

Product Name	Rocepafant
CAS No.	132418-36-1
Molecular Formula	C27H29N3O4
Molecular Weight	459.54 g/mol
Synonyms	Rocepafant; (±)-trans-2-[3-Pyridylmethyl-4-[3-[4-(1H-tetrazol-5-yl)phenyl]propoxy]phenyl]-5,7-dimethylimidazo[1,2-a]pyridine; WEB 2347; WEB-2347; 2-[3-[(3-Pyridinyl)methyl]-4-[3-[4-(1H-tetrazol-5-yl)phenyl]propoxy]phenyl]-5,7-dimethylimidazo[1,2-a]pyridine
EINECS	Contact for details

Quality Control

Our Rocepafant is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, IR and NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and all relevant specifications is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.