Description

Amphotericin B o-Methyloxime CAS NO 132202-02-9 is a chemically modified derivative of the potent polyene macrolide antifungal agent, Amphotericin B. This semi-synthetic compound is engineered to potentially enhance the therapeutic profile by altering solubility and reducing toxicity, which is critical for advanced pharmaceutical development. It is primarily targeted at research institutions and pharmaceutical manufacturers engaged in the discovery and formulation of novel antifungal therapies and drug delivery systems.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of new antifungal agents with improved efficacy and safety margins.
• Antifungal Agent Development: Used as a lead compound for structural-activity relationship (SAR) studies to develop derivatives with enhanced pharmacological properties.
• Biochemical Research: Employed in microbiological and cell-based assays to investigate mechanisms of action against fungal pathogens and study membrane interactions.
• Formulation Studies: Utilized in developing advanced drug delivery systems, such as liposomal or nanoparticle formulations, aimed at targeted therapy.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory compliance in pharmaceutical manufacturing.

Basic Information

Product Name	Amphotericin B o-Methyloxime
CAS No.	132202-02-9
Molecular Formula	C47H73NO18
Molecular Weight	940.08 g/mol
Synonyms	Amphotericin B Methyloxime; Amphotericin B O-Methyloxime; 35-[[3-Amino-3,6-dideoxy-β-D-mannopyranosyl]oxy]-1,3,5,7,9,11,13,15, 24,26,32,34,36-tridecahydroxy-15-[(1E)-1-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]-2-hydroxyethyl]-16,30,31,33-tetramethyl-12-oxo-10,17-dioxa-28-azapentacyclo[25.5.2.12,5.03,25.09,23]hexatriaconta-2(36),3(25),4,6,8,20,22,24,26,33-decaen-34-yl 3-amino-3,6-dideoxy-β-D-mannopyranoside; Amphotericin B Oxime Methyl Ether
EINECS	Contact for details

Quality Control

Our Amphotericin B o-Methyloxime is manufactured under controlled conditions to ensure high purity and consistency, suitable for research and development purposes. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.