Description

(24R)-Paricalcitol CAS NO 132015-95-3 is a synthetic, biologically active vitamin D2 analog, specifically the 24R stereoisomer of paricalcitol. This compound is of significant commercial and therapeutic importance due to its selective action on the vitamin D receptor, offering a targeted approach to regulating calcium and phosphorus metabolism. It is primarily required by the pharmaceutical industry for the development and production of medications aimed at managing secondary hyperparathyroidism associated with chronic kidney disease.

Application

• Active Pharmaceutical Ingredient (API): Primary use in the formulation of injectable and oral medications for treating secondary hyperparathyroidism in patients with chronic kidney disease (CKD) on dialysis.
• Pharmaceutical Research & Development: Serves as a critical reference standard and starting material in the R&D of new vitamin D receptor modulators and related therapeutic agents.
• Biochemical Research: Used in laboratory studies to investigate the mechanisms of vitamin D receptor activation, gene regulation, and mineral homeostasis.
• Veterinary Medicine: Potential application in developing treatments for calcium and bone disorders in animals.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the commercial-scale production of finished dosage forms.

Basic Information

Product Name	(24R)-Paricalcitol
CAS No.	132015-95-3
Molecular Formula	C27H44O3
Molecular Weight	416.64 g/mol
Synonyms	Paricalcitol (24R-isomer); 19-Nor-1α,3β,25-trihydroxy-9,10-secoergosta-5(Z),7(E),22(E)-trien-24-one; (24R)-19-Nor-1,25-dihydroxyvitamin D2; Zemplar® (Active Isomer); 24-epi-Paricalcitol; (24R)-1α,25-Dihydroxy-19-norvitamin D2; 132015-95-3
EINECS	Contact for details

Quality Control

Our (24R)-Paricalcitol is manufactured under strict quality systems suitable for pharmaceutical applications. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets stringent specifications. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, residual solvents, and other critical parameters is provided with every shipment to guarantee traceability and compliance with cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.