Description

6-(1-Hydroxyethyl)-2-Methyl-1-Oxa-2-Penem-3-Carboxylic Acid is a key penem-based intermediate in the synthesis of advanced β-lactam antibiotics. This compound matters for its role as a crucial building block in developing potent, broad-spectrum antibacterial agents with enhanced stability profiles. Pharmaceutical R&D and manufacturing organizations need this high-purity intermediate to produce next-generation carbapenem and penem antibiotics targeting resistant bacterial infections.

Application

• Pharmaceutical Intermediate: Primary use as a critical synthetic precursor for carbapenem-class antibiotics like Meropenem and Biapenem.
• Antibacterial Agent Synthesis: Serves as a core scaffold in the research and development of novel broad-spectrum penem antibiotics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the efficacy and pharmacokinetic properties of β-lactam drugs.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the commercial-scale production of finished dosage forms for injectable antibiotics.
• Biochemical Research: Utilized as a tool compound in studies of bacterial cell wall synthesis and β-lactamase inhibition mechanisms.

Basic Information

Product Name	6-(1-Hydroxyethyl)-2-Methyl-1-Oxa-2-Penem-3-Carboxylic Acid
CAS No.	132015-03-3
Molecular Formula	C9H11NO5
Molecular Weight	213.19 g/mol
Synonyms	(5R,6S)-6-[(1R)-1-Hydroxyethyl]-2-methyl-1-oxa-2-penem-3-carboxylic Acid; 6-(1-Hydroxyethyl)-2-methyl-1-oxa-2-penem-3-carboxylic Acid; Penem Carboxylic Acid Derivative; Meropenem Intermediate; Biapenem Intermediate; 1-Oxa-2-penem-3-carboxylic acid, 6-(1-hydroxyethyl)-2-methyl-; β-Lactam Intermediate
EINECS	Contact for details

Quality Control

Our 6-(1-Hydroxyethyl)-2-Methyl-1-Oxa-2-Penem-3-Carboxylic Acid is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. The product undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent batch-to-batch quality. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with each shipment to support your regulatory and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.