Description

19-Nor-Doxercalciferol is a synthetic analog of vitamin D, specifically engineered for enhanced biological activity and research utility. This compound is of significant interest in the development of novel therapeutic agents targeting calcium and phosphate metabolism. It serves as a critical intermediate and reference standard for pharmaceutical R&D, particularly in the study of bone disorders and endocrine regulation. Global suppliers and research institutions require this high-purity material for advanced synthesis and analytical applications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced vitamin D analogs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard and probe in studies of vitamin D receptor (VDR) signaling and function.
• Metabolic Disorder Studies: Investigated for potential applications in treating conditions like osteoporosis, secondary hyperparathyroidism, and psoriasis.
• Analytical Standard: Serves as a high-purity calibrant for HPLC, LC-MS, and other analytical methods in quality control laboratories.
• Preclinical Development: Utilized in the early-stage development and screening of new therapeutic candidates targeting mineral homeostasis.

Basic Information

Product Name	19-Nor-Doxercalciferol
CAS No.	131918-62-2
Molecular Formula	C₂₇H₄₄O₂
Molecular Weight	400.64 g/mol
Synonyms	1α-Hydroxyergocalciferol; 1α-Hydroxyvitamin D₂; 1α-OH-D₂; 19-Nor-1α-hydroxyvitamin D₂; (5Z,7E)-(1S,3R)-1,3-Dihydroxy-9,10-secoergosta-5,7,10(19),22-tetraen-24-one; Paricalcitol intermediate; Zemplar intermediate; 19-Nor-D2
EINECS	Contact for details

Quality Control

Our 19-Nor-Doxercalciferol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade specifications. Our quality commitment supports reliable sourcing for critical pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.