Description

Paricalcitol is a synthetic, biologically active vitamin D2 analog, specifically designed to activate the vitamin D receptor. This compound is a critical active pharmaceutical ingredient (API) valued for its selective action on parathyroid hormone (PTH) suppression with a reduced effect on serum calcium and phosphorus levels. It is primarily required by pharmaceutical manufacturers and research institutions developing treatments for secondary hyperparathyroidism associated with chronic kidney disease. Our supply of Paricalcitol CAS NO 131918-61-1 ensures high purity and reliable consistency for demanding pharmaceutical applications.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable and oral formulations for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease, particularly those on dialysis.
• Clinical Research: Utilized in preclinical and clinical studies to investigate new therapeutic protocols for mineral and bone disorders.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical method development in pharmaceutical laboratories.
• Drug Development: Used in the R&D of new drug delivery systems and combination therapies targeting the vitamin D endocrine system.
• Biochemical Research: Employed in studies of vitamin D receptor (VDR) signaling pathways and gene regulation mechanisms.

Basic Information

Item	Detail
Product Name	Paricalcitol
CAS No.	131918-61-1
Molecular Formula	C27H44O3
Molecular Weight	416.64 g/mol
Synonyms	19-Nor-1,25-dihydroxyvitamin D2; 19-Nor-1α,25-Dihydroxyvitamin D2; Zemplar (Brand Name); 1α,25-Dihydroxy-19-norvitamin D2; (1R,3S)-5-[2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
EINECS	Contact for details

Quality Control

Our Paricalcitol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and potency, identification by spectroscopic methods (IR, NMR), and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) that detail all test results against relevant in-house and pharmacopeial standards. Our quality commitment ensures the material is suitable for advanced pharmaceutical development and manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider using desiccants and storing under an inert atmosphere to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.