Description

19-Nor-Alfacalcidol is a synthetic analog of vitamin D, specifically a derivative of alfacalcidol with a modified side chain. This compound is a key pharmaceutical intermediate and research chemical with significant biological activity related to calcium and phosphate metabolism. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development of treatments for bone disorders and metabolic diseases. The product is supplied under high-purity conditions to ensure optimal performance in sensitive applications.

Application

• Pharmaceutical Intermediate: Critical raw material in the synthesis of advanced vitamin D analogs and active pharmaceutical ingredients (APIs).
• Research & Development: Used in biochemical and pharmacological studies to investigate vitamin D receptor (VDR) activity and signaling pathways.
• Metabolic Disorder Research: Applied in preclinical research for conditions like osteoporosis, renal osteodystrophy, and hypoparathyroidism.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	19-Nor-Alfacalcidol
CAS No.	131918-60-0
Molecular Formula	C₂₆H₄₂O₃
Molecular Weight	402.61 g/mol
Synonyms	19-Nor-1α-hydroxyvitamin D3; 19-Nor-1α-OH-D3; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1α,3β-diol; 1α-Hydroxy-19-norvitamin D3; 19-Nor-1α,25-Dihydroxyvitamin D3 analog; Nor-Alfacalcidol; 19-Nor Alfacalcidol
EINECS	Contact for details

Quality Control

Our 19-Nor-Alfacalcidol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.