Description

Lexacalcitol is a synthetic vitamin D3 analog, a potent and selective activator of the vitamin D receptor (VDR). This compound is of significant interest for its targeted biological activity, offering a high degree of specificity in modulating calcium and phosphate metabolism. It is primarily utilized in advanced pharmaceutical research and development for metabolic bone disorders and related endocrine research.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel vitamin D receptor modulators and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard and tool compound in studies investigating vitamin D receptor signaling pathways and gene regulation.
• Drug Discovery & Development: Employed in preclinical research for developing new therapeutics targeting osteoporosis, secondary hyperparathyroidism, and psoriasis.
• Metabolic Studies: Applied in laboratory investigations to understand calcium homeostasis, bone mineralization, and cell differentiation processes.

Basic Information

Product Name	Lexacalcitol
CAS No.	131875-08-6
Molecular Formula	C29H44O3
Molecular Weight	440.66 g/mol
Synonyms	1α,25-Dihydroxy-22-oxavitamin D3; 22-Oxacalcitriol; OCT; 1α,25-Dihydroxy-22-oxavitamin D3; 1α,25-Dihydroxy-22-oxacholecalciferol; 22-Oxa-1α,25-dihydroxyvitamin D3; KH 1060
EINECS	Contact for details

Quality Control

Our Lexacalcitol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label. Due to its sensitivity to light and oxidation, the container should only be opened in a controlled environment and material should be used promptly.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solvent Residues (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.