Description

7,12-Dihydroxy-3-(2-(Glucopyranosyl)Acetyl)Cholan-24-Oic Acid CAS NO 131528-41-1 is a high-purity, conjugated bile acid derivative with a glucopyranosyl moiety. This compound is valued for its role as a key intermediate and reference standard in advanced pharmaceutical research and development. It is primarily utilized by research institutions and manufacturers in the life sciences sector focusing on metabolic pathways, hepatobiliary function, and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Critical starting material or building block in the synthesis of novel therapeutic compounds targeting liver and metabolic diseases.
• Biochemical Research: Used as a reference standard or probe in studies of bile acid metabolism, transport proteins (e.g., ASBT, NTCP), and nuclear receptor signaling (e.g., FXR, TGR5).
• Analytical Standard: Serves as a high-purity calibrant or control in HPLC, LC-MS, and other analytical methods for quantifying bile acids in biological samples.
• Enzymology Studies: Substrate for investigating the activity of enzymes involved in bile acid conjugation and modification, such as bile acid-CoA:amino acid N-acyltransferase (BAAT).
• Cell Culture & In Vitro Assays: Employed in cell-based assays to study cytotoxicity, cholestasis, and the protective effects of bile acids in hepatocyte models.
• Nutraceutical R&D: Investigated for potential applications in developing targeted supplements for digestive and metabolic health.

Basic Information

Product Name	7,12-Dihydroxy-3-(2-(Glucopyranosyl)Acetyl)Cholan-24-Oic Acid
CAS No.	131528-41-1
Molecular Formula	C₃₂H₅₂O₁₂
Molecular Weight	628.75 g/mol
Synonyms	3-(2-Glucopyranosylacetyl)-7,12-dihydroxycholan-24-oic Acid; Taurohyodeoxycholic Acid 3-Glucuronide (related analog); Glycochenodeoxycholic Acid 3-Glucoside (structural analog); Cholan-24-oic Acid, 7,12-dihydroxy-3-[(2-O-β-D-glucopyranosyl)acetyl]-; Bile Acid Glucoside Conjugate; 3-β-D-Glucopyranosylacetoxy-7α,12α-dihydroxy-5β-cholan-24-oic Acid
EINECS	Contact for details

Quality Control

Our 7,12-Dihydroxy-3-(2-(Glucopyranosyl)Acetyl)Cholan-24-Oic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.