Description

1-Piperazineethanol, 4-(4-Amino-6,7-Dimethoxy-2-Quinazolinyl)-α-(2 ,3-Dihydro-2-Methyl-1,4-Benzodioxin-2-Yl)-, Hydrochloride is a high-purity, complex heterocyclic compound designed for advanced pharmaceutical synthesis. This product is critical for research and development in medicinal chemistry, particularly as a sophisticated building block or intermediate. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel drug candidates, particularly those targeting complex biological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its intricate molecular architecture.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the multi-step synthesis of potential APIs, especially in oncology and central nervous system (CNS) therapeutic areas.
• Biochemical Research: Acts as a tool compound or a ligand in biochemical assays to study enzyme inhibition or receptor binding.
• Process Development & Scale-Up: Utilized by process chemists to develop and optimize scalable synthetic routes for pilot and commercial manufacturing.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical analysis.

Basic Information

Product Name	1-Piperazineethanol, 4-(4-Amino-6,7-Dimethoxy-2-Quinazolinyl)-α-(2 ,3-Dihydro-2-Methyl-1,4-Benzodioxin-2-Yl)-, Hydrochloride
CAS No.	130045-74-8
Molecular Formula	C26H33N5O5 • HCl
Molecular Weight	524.04 g/mol (free base: 487.57 g/mol)
Synonyms	4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-α-(2,3-dihydro-2-methyl-1,4-benzodioxin-2-yl)-1-piperazineethanol hydrochloride; 1-Piperazineethanol, 4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-α-(2,3-dihydro-2-methyl-1,4-benzodioxin-2-yl)-, monohydrochloride; (R)-4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-α-(2-methyl-2,3-dihydro-1,4-benzodioxin-2-yl)-1-piperazineethanol hydrochloride; Potential intermediate for Doxazosin; Doxazosin Impurity; Doxazosin Related Compound; Benzodioxinyl quinazolinyl piperazineethanol hydrochloride
EINECS	Contact for details

Quality Control

Our 1-Piperazineethanol, 4-(4-Amino-6,7-Dimethoxy-2-Quinazolinyl)-α-(2 ,3-Dihydro-2-Methyl-1,4-Benzodioxin-2-Yl)-, Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.