Description

(-)-1-[(4-Chlorophenyl) Phenylmethyl] Piperazine is a high-purity chiral piperazine derivative, a critical building block in advanced organic synthesis. Its enantiomeric purity and defined stereochemistry make it an essential intermediate for the development of active pharmaceutical ingredients (APIs) and fine chemicals. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with specific biological activity.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of central nervous system (CNS) agents, receptor antagonists, and other bioactive molecules.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, leveraging its structural motif for target specificity.
• Catalyst Ligand Synthesis: Serves as a precursor for chiral ligands used in asymmetric catalysis to produce enantiomerically pure compounds.
• Fine Chemical Production: Employed in custom synthesis and contract manufacturing for high-value, low-volume specialty chemicals.
• Academic & Industrial R&D: A valuable reagent for medicinal chemistry programs and structure-activity relationship (SAR) studies in drug discovery.

Basic Information

Product Name	(-)-1-[(4-Chlorophenyl) Phenylmethyl] Piperazine
CAS No.	130018-88-1
Molecular Formula	C17H19ClN2
Molecular Weight	286.80 g/mol
Synonyms	(-)-1-(4-Chlorobenzhydryl)piperazine; (S)-1-[(4-Chlorophenyl)(phenyl)methyl]piperazine; 1-[(4-Chlorophenyl)phenylmethyl]piperazine, (-)-; Levocetirizine Impurity F; Cetirizine Related Compound F; (S)-1-(4-Chloro-α-phenylbenzyl)piperazine; 130018-88-1; UNII-9I0I8R2C8H
EINECS	Contact for details

Quality Control

Our (-)-1-[(4-Chlorophenyl) Phenylmethyl] Piperazine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity assay and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.