Description

n-Boc-Piperazine-2-Carboxylic Acid Methyl Ester is a protected amino acid derivative and a key chiral building block in organic synthesis. This compound is valued for its role in introducing the piperazine-2-carboxylate moiety under controlled conditions, which is crucial for constructing complex molecular architectures. It is primarily utilized by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, antiviral agents, and protease inhibitors.
• Peptidomimetics Research: Serves as a constrained scaffold in the design and synthesis of peptidomimetics, helping to improve metabolic stability and bioavailability of peptide-based therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the piperazine core contributes to biological activity.
• Chemical Biology & Proteomics: Employed as a building block for creating chemical probes and affinity tags to study enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects requiring high-purity, advanced intermediates for scale-up under GMP or non-GMP conditions.

Basic Information

Product Name	n-Boc-Piperazine-2-Carboxylic Acid Methyl Ester
CAS No.	129799-15-1
Molecular Formula	C11H20N2O4
Molecular Weight	244.29 g/mol
Synonyms	1-Boc-2-piperazinecarboxylic acid methyl ester; Methyl 1-(tert-butoxycarbonyl)piperazine-2-carboxylate; tert-Butyl 2-(methoxycarbonyl)piperazine-1-carboxylate; 1-N-Boc-piperazine-2-carboxylic acid methyl ester; (S)-1-Boc-piperazine-2-carboxylic acid methyl ester (if applicable to specific enantiomer); (R)-1-Boc-piperazine-2-carboxylate methyl ester (if applicable to specific enantiomer); Boc-Pip-OMe; Piperazine-2-carboxylic acid, 1-(1,1-dimethylethoxy)carbonyl-, methyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-Piperazine-2-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the high standards required for research and cGMP manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (for enantiopure grade)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.