Description

4-Cbz-Piperazine-2-Carboxylate Methyl Ester is a versatile and high-purity protected piperazine derivative, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the controlled construction of complex molecular architectures, particularly for pharmaceuticals, by providing a reactive carboxylate ester and a protected amine for selective functionalization. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for API synthesis and novel compound library development.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Peptidomimetic Research: Used in the design and synthesis of peptide analogs and constrained scaffolds to improve metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material for the preparation of enantiomerically pure compounds via stereoselective transformations.
• Chemical Biology Probes: Utilized in the development of molecular probes and tool compounds for target validation and mechanism-of-action studies.
• Agrochemical Development: Intermediate in the synthesis of novel herbicides, fungicides, and insecticides that incorporate the piperazine pharmacophore.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up campaigns under cGMP or ISO quality systems.

Basic Information

Product Name	4-Cbz-Piperazine-2-Carboxylate Methyl Ester
CAS No.	129799-11-7
Molecular Formula	C15H20N2O4
Molecular Weight	292.33 g/mol
Synonyms	Methyl 1-[(benzyloxy)carbonyl]-2-piperazinecarboxylate; 1-Cbz-2-Piperazinecarboxylic Acid Methyl Ester; 1-Benzyloxycarbonyl-2-piperazinecarboxylic Acid Methyl Ester; Methyl 1-(benzyloxycarbonyl)piperazine-2-carboxylate; Methyl N-Cbz-piperazine-2-carboxylate; 1-CBZ-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER; (S)-Methyl 1-((benzyloxy)carbonyl)piperazine-2-carboxylate (for enantiopure form); Piperazine-2-carboxylic acid, 1-[(phenylmethoxy)carbonyl]-, methyl ester
EINECS	Contact for details

Quality Control

Our 4-Cbz-Piperazine-2-Carboxylate Methyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, chiral purity (where applicable), and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications and test results are available for every batch and provided upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.