Description

1-Boc-3,5-Dimethyl-Piperazine is a high-purity, protected piperazine derivative widely used as a critical building block in organic synthesis. Its primary value lies in providing a sterically hindered, secondary amine nitrogen that is protected by the acid-labile tert-butoxycarbonyl (Boc) group, enabling selective deprotection in multi-step synthetic sequences. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the development of novel pesticides, herbicides, and fungicides where the dimethyl-piperazine scaffold imparts specific biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral and achiral ligands used in asymmetric catalysis and metal complex formation.
• Peptidomimetics & PROTACs: Incorporated into the backbone of peptide mimics and Proteolysis Targeting Chimeras (PROTACs) due to its conformational rigidity and amine functionality.
• Chemical Biology Research: Employed as a scaffold for constructing molecular probes and libraries to study protein-protein interactions and enzyme function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	1-Boc-3,5-Dimethyl-Piperazine
CAS No.	129779-30-2
Molecular Formula	C11H22N2O2
Molecular Weight	214.31 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-3,5-dimethylpiperazine; tert-Butyl 3,5-dimethylpiperazine-1-carboxylate; 3,5-Dimethylpiperazine-1-carboxylic acid tert-butyl ester; 1-Boc-3,5-dimethylpiperazine; N-Boc-3,5-dimethylpiperazine; Boc-3,5-dimethylpiperazine; 1-N-Boc-3,5-dimethylpiperazine
EINECS	Contact for details

Quality Control

Our 1-Boc-3,5-Dimethyl-Piperazine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting the results against our stringent internal specifications. Our commitment to cGMP (current Good Manufacturing Practice) principles ensures a reliable supply of high-quality material suitable for advanced research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.