Description

Amino-Peg10-Alcohol CAS NO 129449-09-8 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine group at one terminus and a hydroxyl group at the other, separated by a ten-unit PEG spacer. This unique structure provides exceptional water solubility, biocompatibility, and a versatile platform for conjugation chemistry, enabling the modification of biomolecules, surfaces, and nanoparticles. It is an essential building block for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, where controlled functionalization and linker design are critical.

Application

• Bioconjugation and Linker Chemistry: Used to conjugate drugs, dyes, or other functional molecules to proteins, antibodies, peptides, and oligonucleotides, improving solubility and pharmacokinetics.
• PEGylation Reagent: Serves as a functional PEG spacer for the site-specific PEGylation of therapeutic proteins and peptides to enhance stability and reduce immunogenicity.
• Surface Functionalization: Employed to modify nanoparticles, quantum dots, and solid supports (e.g., glass, gold) with amine or hydroxyl groups for subsequent coupling or to create hydrophilic, non-fouling surfaces.
• Crosslinking Agent: Acts as a heterobifunctional crosslinker for creating hydrogels, polymer networks, or conjugating two different molecules via amine- and hydroxyl-reactive chemistries.
• Diagnostic Reagent Synthesis: A key intermediate in the synthesis of contrast agents, fluorescent probes, and other diagnostic tools requiring water-soluble linkers.
• Polymer and Dendrimer Synthesis: Utilized as a monomer or building block for constructing functionalized polymers, dendrimers, and complex macromolecular architectures.

Basic Information

Item	Details
Product Name	Amino-Peg10-Alcohol
CAS No.	129449-09-8
Molecular Formula	C22H47NO11 (or variable based on PEG distribution)
Molecular Weight	~ 501.6 g/mol (for exact monodisperse form)
Synonyms	2,5,8,11,14,17,20,23,26,29-Decaoxa-32-azahentetracontan-32-ol; 19-Amino-4,7,10,13,16-pentaoxanonadecan-1-ol; Amino-PEG10-OH; H2N-PEG10-OH; α-Amino-ω-hydroxy-poly(ethylene glycol); 1-Amino-11-hydroxy-3,6,9-trioxaundecane (core unit descriptor); Heterobifunctional PEG 10, Amine-PEG10-Alcohol; NH2-PEG10-OH
EINECS	Contact for details

Quality Control

Our Amino-Peg10-Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight distribution, and functional group integrity. We provide comprehensive Certificates of Analysis (COA) detailing specifications for identity, assay, and impurities. Quality standards are aligned with cGMP principles for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Under recommended storage conditions, the product is stable for at least 24 months from the date of receipt. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Functional Groups)	≥ 90% (by titration/NMR)
Water Content (KF)	≤ 1.0%
Molecular Weight (GPC/SEC)	Confirmatory data provided
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.