Description

1-Cbz-Piperazine-2-Carboxylic Acid is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block for constructing complex molecular architectures, offering precise control over stereochemistry. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and specialized chemical libraries.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce constrained piperazine scaffolds, modifying peptide backbone properties.
• Chemical Library Synthesis: Employed in combinatorial chemistry and parallel synthesis for creating diverse screening libraries focused on protease inhibitors or GPCR modulators.
• Protecting Group Strategy: The Cbz (carboxybenzyl) group provides orthogonal protection for the piperazine nitrogen, enabling sequential deprotection in multi-step syntheses.
• Ligand and Catalyst Development: Acts as a precursor for chiral ligands used in asymmetric catalysis, such as in hydrogenation or cross-coupling reactions.

Basic Information

Product Name	1-Cbz-Piperazine-2-Carboxylic Acid
CAS No.	129365-24-8
Molecular Formula	C13H16N2O4
Molecular Weight	264.28 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-2-piperazinecarboxylic Acid; (S)-1-Cbz-Piperazine-2-Carboxylic Acid; 1-Carbobenzyloxy-piperazine-2-carboxylic Acid; 1-N-Cbz-Piperazine-2-carboxylic Acid; 1-Benzyloxycarbonylpiperazine-2-carboxylic Acid; (Piperazin-1-yl)(phenyl)methanone 2-carboxylic acid derivative; Z-Pip(2)-OH
EINECS	Contact for details

Quality Control

Our 1-Cbz-Piperazine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) providing HPLC purity, chiral HPLC data, and residual solvent analysis is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.