Description

n-1-Boc-n-4-Cbz-2-Piperazinecarboxylic Acid T-Butyl Ester CAS NO 129365-23-7 is a high-purity, protected piperazine derivative widely used as a critical building block in organic synthesis. This compound is essential for researchers and manufacturers requiring precise molecular architecture, particularly in the development of complex active pharmaceutical ingredients (APIs). It is primarily utilized by the pharmaceutical, agrochemical, and advanced materials industries for constructing sophisticated nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, including kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Peptidomimetic Chemistry: Serves as a constrained scaffold for designing and synthesizing peptide analogs and mimetics with enhanced metabolic stability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that incorporate a functionalized piperazine core.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for client R&D programs.
• Academic Research: Utilized in university and institutional labs for methodological studies in heterocyclic and medicinal chemistry.

Basic Information

Product Name	n-1-Boc-n-4-Cbz-2-Piperazinecarboxylic Acid T-Butyl Ester
CAS No.	129365-23-7
Molecular Formula	C22H32N2O6
Molecular Weight	420.50 g/mol
Synonyms	1-Boc-4-Cbz-2-Piperazinecarboxylic Acid t-Butyl Ester; tert-Butyl 1-[(benzyloxy)carbonyl]-4-(tert-butoxycarbonyl)piperazine-2-carboxylate; 1-N-Boc-4-N-Cbz-piperazine-2-carboxylic Acid t-Butyl Ester; 4-[(Benzyloxy)carbonyl]-1-[(tert-butoxy)carbonyl]piperazine-2-carboxylic Acid 1,1-Dimethylethyl Ester; Boc-Cbz-Pip-OtBu; (2S)-1,4-Bis[(tert-butoxy)carbonyl]piperazine-2-carboxylic Acid Benzyl Ester (related isomer); Piperazine-2-carboxylic acid, 1,4-bis[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester (registry listing)
EINECS	Contact for details

Quality Control

Our n-1-Boc-n-4-Cbz-2-Piperazinecarboxylic Acid T-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.