Description

Dpq CAS NO 129075-73-6 is a specialized organic compound widely recognized as a potent and selective inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). This compound matters significantly in biochemical research for its role in studying DNA repair mechanisms, cellular stress responses, and pathways related to cancer and neurodegeneration. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on developing novel therapeutic strategies and understanding fundamental cellular processes.

Application

• Biochemical Research: Used as a selective PARP-1 inhibitor to study the enzyme's role in DNA repair, genomic stability, and cell death pathways.
• Oncology Studies: A critical tool in cancer research to investigate synthetic lethality, particularly in BRCA-deficient cancer models, and to evaluate potential chemosensitizing agents.
• Neuropharmacology: Employed in research models of stroke, traumatic brain injury, and neurodegenerative diseases to examine PARP-mediated cell death and neuroinflammation.
• Cardiovascular Research: Applied in studies of myocardial ischemia-reperfusion injury to understand the involvement of PARP activation in cardiac dysfunction.
• Inflammatory Disease Models: Utilized to probe the role of PARP in various inflammatory conditions, including septic shock and arthritis.
• Drug Discovery & Development: Serves as a reference compound and a starting point for the design and screening of new PARP inhibitor candidates.

Basic Information

Product Name	Dpq
CAS No.	129075-73-6
Molecular Formula	C₁₄H₁₂N₄O
Molecular Weight	252.27 g/mol
Synonyms	3,4-Dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone; 1(2H)-Isoquinolinone, 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-; DPQ; PARP-1 Inhibitor III; 5-[4-(Piperidin-1-yl)butoxy]-3,4-dihydro-1H-isoquinolin-2-one; GPI 6150; GPI-6150
EINECS	Contact for details

Quality Control

Our Dpq is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity determination and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The compound is stable under these conditions for extended periods. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.