Description

(6S)-6-(Hydroxymethyl)-2-Piperidinone CAS NO 128726-47-6 is a high-purity chiral piperidinone derivative, a key building block in advanced organic synthesis. Its value lies in its stereochemically defined structure, which is critical for imparting specific biological activity in final pharmaceutical compounds. This intermediate is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapies.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Research: Serves as a core structural component in the development of protease inhibitors for antiviral and anticancer applications.
• Neurological Drug Development: Used in constructing pharmacophores for potential treatments targeting neurological disorders and pain management.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective chemical reactions to create enantiomerically pure compounds.
• Peptidomimetics: Incorporated into the design of peptide-like molecules that mimic the structure and function of natural peptides.
• Chemical Biology & Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies and the creation of targeted molecular libraries for high-throughput screening.

Basic Information

Product Name	(6S)-6-(Hydroxymethyl)-2-Piperidinone
CAS No.	128726-47-6
Molecular Formula	C6H11NO2
Molecular Weight	129.16 g/mol
Synonyms	(6S)-6-(Hydroxymethyl)piperidin-2-one; (S)-6-(Hydroxymethyl)piperidin-2-one; (S)-6-(Hydroxymethyl)-2-piperidinone; L-6-Hydroxymethyl-2-piperidinone; (S)-(-)-6-Hydroxymethyl-2-piperidone; 2-Piperidinone, 6-(hydroxymethyl)-, (6S)-; (6S)-6-Hydroxymethyl-2-piperidone
EINECS	Contact for details

Quality Control

Our (6S)-6-(Hydroxymethyl)-2-Piperidinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.