Description

10,20-Methanoretinal is a specialized synthetic retinoid derivative, a key advanced intermediate in the research and development of novel vitamin A analogs. This compound matters for its precise molecular architecture, which is critical for studying retinoid receptor activity and developing targeted therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of high-purity fine chemicals for applications in vision science, dermatology, and oncology research.

Application

• Pharmaceutical Research Intermediate: A crucial building block for the synthesis of novel retinoid-based drug candidates targeting nuclear receptors.
• Biochemical Research: Used in studies of visual pigment regeneration, retinal metabolism, and photoreceptor cell biology.
• Dermatological Agent Development: Serves as a precursor in the development of new-generation topical treatments for acne, psoriasis, and photoaging.
• Oncology Research: Employed in the synthesis of experimental compounds for investigating retinoid pathways in cancer cell differentiation and apoptosis.
• Reference Standard: Utilized as a high-purity analytical standard in HPLC and LC-MS methods for quality control of related retinoid substances.
• Fine Chemical Synthesis: Acts as a key chiral synthon in the multi-step synthesis of complex, biologically active molecules.

Basic Information

Product Name	10,20-Methanoretinal
CAS No.	128434-80-0
Molecular Formula	C21H28O
Molecular Weight	296.45 g/mol
Synonyms	10,20-Methano-retinal; (11E,13E)-11,13-Dimethyl-10,20-methanoretinal; 10,20-Methanorhodopsin Chromophore; Retinal, 10,20-methano-; Vitamin A aldehyde analog; Locked-retinal analog; Cyclopropyl-retinal derivative
EINECS	Contact for details

Quality Control

Our 10,20-Methanoretinal is produced under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for demanding research applications. Quality is assured through comprehensive analytical testing including HPLC, NMR, and GC-MS. A Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with each batch. We adhere to cGMP principles where applicable to support preclinical and development-phase requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. The container should be allowed to reach room temperature before opening to minimize moisture condensation. Keep away from oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.