Description

(1R)-1,2,4,7,8,8Aα-Hexahydro-1-Isopropyl-3,6-Dimethylazulene-1β,8α-Diol is a high-purity, stereochemically defined sesquiterpenoid diol of significant interest in advanced organic synthesis and pharmaceutical research. Its rigid, functionalized azulene-derived structure makes it a valuable chiral building block for the development of complex molecules and active pharmaceutical ingredients (APIs). This compound is primarily sought by research institutions and industrial R&D departments focused on medicinal chemistry, fragrance development, and the synthesis of novel natural product analogs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel therapeutic agents, particularly in anti-inflammatory and anti-cancer research.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and lead optimization due to its complex, polycyclic framework.
• Fragrance & Flavor Synthesis: Acts as a starting material for creating unique sesquiterpenoid-based aroma chemicals with woody, amber-like olfactory properties.
• Natural Product Synthesis: A critical intermediate in the total or semi-synthesis of complex natural products belonging to the guaiane and azulene families.
• Asymmetric Catalysis Studies: Employed as a test substrate or ligand precursor in the development of new stereoselective synthetic methodologies.
• Advanced Material Science: Investigated for its potential in creating chiral dopants or organic semiconductors due to its extended π-system.

Basic Information

Product Name	(1R)-1,2,4,7,8,8Aα-Hexahydro-1-Isopropyl-3,6-Dimethylazulene-1β,8α-Diol
CAS No.	128397-34-2
Molecular Formula	C₁₅H₂₆O₂
Molecular Weight	238.37 g/mol
Synonyms	(1R,4S,4aS,8aR)-1,2,3,4,5,6,7,8-Octahydro-1,4-dimethyl-7-(1-methylethyl)azulene-1,4-diol; (1R,4S,4aS,8aR)-1,2,3,4,5,6,7,8-Octahydro-1,4-dimethyl-7-isopropylazulene-1,4-diol; 1,4-Guaianediol (stereoisomer); Guaiane-1,4-diol derivative; (1R,4S,4aS,8aR)-1,4-Dimethyl-7-isopropyloctahydroazulene-1,4-diol; 1β,4α-Guaianediol; Azulene-1,4-diol derivative
EINECS	Contact for details

Quality Control

Our (1R)-1,2,4,7,8,8Aα-Hexahydro-1-Isopropyl-3,6-Dimethylazulene-1β,8α-Diol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure high chemical and stereochemical purity suitable for demanding research applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.