Description

2α-Hydroxy-8β-(2-Methylbutyryloxy)Costunolide is a high-purity, semi-synthetic sesquiterpene lactone derivative of the natural compound costunolide. This specialized intermediate is valued for its enhanced bioactivity and serves as a critical building block in advanced pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the synthesis of novel therapeutic agents and bioactive molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the research and development of anti-inflammatory, anticancer, and antimicrobial drug candidates.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• Natural Product Synthesis: Serves as a versatile chiral starting material or intermediate for the semi-synthesis of complex natural product analogs.
• Agrochemical Development: Investigated for the formulation of new plant growth regulators or bioactive agents with pesticidal or herbicidal activity.
• Biochemical Research: Employed as a tool compound in biochemical assays to study specific enzymatic pathways or cellular mechanisms.
• Reference Standard: Used as an analytical standard in quality control laboratories for the identification and quantification of related sesquiterpene lactones.

Basic Information

Product Name	2α-Hydroxy-8β-(2-Methylbutyryloxy)Costunolide
CAS No.	128286-87-3
Molecular Formula	C₂₁H₃₀O₆
Molecular Weight	378.46 g/mol
Synonyms	2α-Hydroxy-8β-(2-methylbutanoyloxy)costunolide; 8β-(2-Methylbutyryloxy)-2α-hydroxycostunolide; 2α-Hydroxy-8β-(2-methyl-1-oxobutoxy)costunolide; Costunolide, 2α-hydroxy-8β-(2-methylbutyryloxy)-; (2R,3aS,4S,7S,8aR)-4-Hydroxy-7-[(2S)-2-methylbutanoyl]oxy-3a,4,7,8a-tetrahydro-2H-3,6-methanoazulen-2-one
EINECS	Contact for details

Quality Control

Our 2α-Hydroxy-8β-(2-Methylbutyryloxy)Costunolide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and relevant research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.