Description

(R)-2-Methyl-Piperazine-1,4-Dicarboxylic Acid 4-Benzyl Ester 1-tert-Butyl Ester is a high-purity, chiral piperazine derivative used as a critical building block in advanced organic synthesis. This compound matters because it provides a protected, stereochemically defined scaffold essential for constructing complex molecules with high enantiomeric purity. It is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, especially for central nervous system (CNS) and antiviral therapies.
• Peptidomimetic Chemistry: Serves as a constrained dipeptide analog for designing protease inhibitors and bioactive peptides with improved metabolic stability.
• Asymmetric Catalysis Ligand Precursor: Used in the synthesis of chiral ligands and organocatalysts for enantioselective transformations.
• Chemical Biology & Proteomics: Employed in the design of molecular probes and activity-based protein profiling (ABPP) agents to study enzyme function.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring specific stereochemistry and protected functional groups.
• Academic & Institutional Research: Utilized in methodological studies for developing new synthetic routes to complex heterocycles.

Basic Information

Product Name	(R)-2-Methyl-Piperazine-1,4-Dicarboxylic Acid 4-Benzyl Ester 1-tert-Butyl Ester
CAS No.	128102-16-9
Molecular Formula	C18H26N2O4
Molecular Weight	334.41 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)-4-(benzyloxycarbonyl)-2-methylpiperazine; (R)-2-Methyl-1,4-piperazinedicarboxylic Acid 1-tert-Butyl Ester 4-Benzyl Ester; (R)-1-Boc-4-Cbz-2-methylpiperazine; (R)-N-Boc-N'-Cbz-2-methylpiperazine; (R)-2-Methylpiperazine-1,4-dicarboxylate 1-tert-butyl 4-benzyl ester; (2R)-2-Methyl-1,4-piperazinedicarboxylic Acid 1-(1,1-Dimethylethyl) Ester 4-(Phenylmethyl) Ester; (R)-Boc-Cbz-2-methylpiperazine
EINECS	Contact for details

Quality Control

Our (R)-2-Methyl-Piperazine-1,4-Dicarboxylic Acid 4-Benzyl Ester 1-tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.