Description

Bastadin 8 is a brominated tyrosine-derived alkaloid, a member of the bastadin family of marine natural products. This compound is of significant interest in biochemical and pharmacological research due to its potent and specific biological activity as an inhibitor of the IP3 receptor, a key regulator of intracellular calcium signaling. Researchers in drug discovery, chemical biology, and marine pharmacology utilize Bastadin 8 CAS NO 127709-45-9 as a critical tool compound for studying calcium-dependent cellular processes and developing novel therapeutic strategies.

Application

• Biochemical Research: Used as a selective and potent inhibitor of the inositol 1,4,5-trisphosphate (IP3) receptor to study intracellular calcium (Ca²⁺) release and signaling pathways.
• Pharmacological Studies: Serves as a key reference standard and probe in the investigation of calcium-mediated cellular functions, including muscle contraction, neurotransmission, and gene expression.
• Drug Discovery & Development: Acts as a lead compound or molecular template for the design of new therapeutics targeting disorders related to aberrant calcium signaling, such as cardiac arrhythmias and neurological conditions.
• Marine Natural Product Research: Studied for its unique biosynthetic origin and ecological role, contributing to the understanding of marine chemical defense mechanisms.
• Cell Biology Assays: Employed in in vitro and cell-based assays to elucidate the role of IP3 receptors in apoptosis, cell proliferation, and other vital processes.

Basic Information

Item	Detail
Product Name	Bastadin 8
CAS No.	127709-45-9
Molecular Formula	C₃₄H₂₈Br₄N₄O₆
Molecular Weight	908.13 g/mol
Synonyms	Bastadin-8; 5,5'-[1,12-Dodecanediylbis(imino-6,1-hexanediyloxy)]bis[2-bromo-4-hydroxy-3-(4-hydroxyphenyl)benzamide]; IP3 Receptor Inhibitor Bastadin 8; Marine Alkaloid Bastadin 8
EINECS	Contact for details

Quality Control

Our Bastadin 8 is produced and handled under strict quality protocols to ensure the high purity and consistency required for advanced research applications. Each batch undergoes comprehensive analytical characterization, including HPLC for purity assessment and NMR for structural confirmation, to meet exacting research standards. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specific research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.