Description

Bastadin 9 CAS NO 127687-07-4 is a brominated tyrosine-derived alkaloid, a member of the bastadin family of marine natural products originally isolated from marine sponges. This compound is of significant interest in biochemical and pharmacological research due to its potent and selective activity as an inhibitor of the IP3 receptor, a key regulator of intracellular calcium signaling. It serves as a critical research tool for scientists in the fields of cell biology, neurobiology, and drug discovery, enabling the study of calcium-dependent cellular processes and the development of novel therapeutic strategies.

Application

• Biochemical Research: Used as a selective and potent inhibitor of the inositol 1,4,5-trisphosphate (IP3) receptor to study intracellular calcium (Ca²⁺) signaling pathways.
• Cell Biology Studies: Employed to investigate the role of calcium release from the endoplasmic reticulum in processes such as apoptosis, muscle contraction, and neurotransmitter release.
• Neuroscience Research: A valuable tool for probing calcium dynamics in neurons and glial cells, contributing to the understanding of synaptic plasticity and neurological disorders.
• Pharmacological Screening: Serves as a reference compound or a lead structure in drug discovery programs targeting calcium signaling for conditions like cardiac arrhythmias and cancer.
• Marine Natural Product Chemistry: Used as a standard or reference material in the isolation, identification, and synthesis of related brominated tyrosine alkaloids.
• Signal Transduction Assays: Applied in high-throughput or mechanistic assays to dissect the complexities of G-protein coupled receptor (GPCR) and other signaling cascades linked to IP3 production.

Basic Information

Product Name	Bastadin 9
CAS No.	127687-07-4
Molecular Formula	C₃₄H₂₈Br₄N₄O₈
Molecular Weight	956.12 g/mol
Synonyms	Bastadin-9; 5,5'-[1,1'-Biphenyl]-2,2'-diylbis(oxy)]bis[3-bromo-4-[2-(3,5-dibromo-4-hydroxyphenyl)acetamido]benzoic Acid]; IP3 Receptor Inhibitor, Bastadin 9; Marine Sponge Alkaloid Bastadin 9
EINECS	Contact for details

Quality Control

Bastadin 9 is supplied for research use under stringent quality protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic methods (NMR, MS) for structural confirmation, to ensure identity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the purity, assay results, and analytical data. Our quality management system supports the needs of research and development laboratories requiring high-purity, well-characterized biochemical tools.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. The product should be handled in accordance with good laboratory practice.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.