Description

1,2-Dioleoyl-Sn-Glycero-3-Succinate is a synthetic, anionic phospholipid derivative, specifically a succinylated phosphatidylglycerol analog. This compound is a critical functional lipid excipient valued for its ability to form stable, pH-sensitive liposomes and lipid nanoparticles. It is primarily needed by pharmaceutical R&D and formulation scientists working on advanced drug delivery systems, including mRNA vaccines, gene therapy vectors, and targeted cancer therapeutics.

Application

• Lipid Nanoparticle (LNP) Formulation: A key ionizable or helper lipid component for encapsulating nucleic acids (mRNA, siRNA, pDNA) in vaccines and gene therapies.
• pH-Sensitive Liposomes: Used to create fusogenic liposomes that release their cargo in response to the acidic environment of tumor tissues or endosomes.
• Drug Delivery Research: Serves as a model anionic lipid for studying membrane fusion, cellular uptake, and intracellular trafficking mechanisms.
• Biomimetic Membrane Systems: Incorporated into artificial membranes and vesicles for biophysical studies and diagnostic assay development.
• Cosmetic Actives Delivery: Employed in high-end cosmetic formulations to enhance the skin penetration and stability of active ingredients.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Succinate
CAS No.	127640-49-7
Molecular Formula	C47H85O10
Molecular Weight	810.17 g/mol
Synonyms	DOGS; 1,2-Dioleoyl-sn-glycero-3-succinyl; Dioleoyl succinylglycerol; Succinyl phosphatidylglycerol; 3'-Succinyl-1,2-dioleoyl-sn-glycerol; 1,2-Di-(9Z-octadecenoyl)-sn-glycero-3-succinate; N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl-sulfate (common mis-association, included for clarity); Cationic lipid DOGS (historical context)
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Succinate is produced under strict quality management systems. Each batch is characterized and tested to ensure identity, purity, and consistency suitable for pharmaceutical research and formulation. We provide comprehensive Certificates of Analysis (COA) with data for critical parameters including HPLC purity, structural confirmation (NMR, MS), and lipid peroxidation indices. Specifications can be aligned with cGMP guidelines for advanced therapeutic medicinal product (ATMP) development upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation. The product is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided.

Specification

Item	Specification
Appearance	White to off-white waxy solid or oil
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
1,2-Dioleoyl Isomer Content	≥ 90.0%
Acid Value	Contact for details
Peroxide Value	< 5.0 meq/kg
Solvent Residues (GC)	Meets ICH guidelines
Water Content (KF)	< 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.