Description

N(5)-Piperazine-Amiloride is a high-purity chemical intermediate and research compound, primarily recognized for its role as a key building block in pharmaceutical synthesis. Its value lies in its specific molecular structure, which is integral to developing novel compounds for research and development. This product is essential for pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on creating new therapeutic agents, particularly in areas involving ion channel modulation.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel amiloride analogs and other bioactive molecules.
• Biochemical Research: Used as a tool compound in studies investigating sodium channel (ENaC) and sodium-hydrogen exchanger (NHE) mechanisms.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop new drug candidates with potential diuretic or anti-hypertensive properties.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic Research: Applied in university and institutional labs for fundamental research in pharmacology and cellular physiology.

Basic Information

Product Name	N(5)-Piperazine-Amiloride
CAS No.	127628-91-5
Molecular Formula	C12H19ClN6O
Molecular Weight	298.78 g/mol
Synonyms	5-(N-Piperazinyl)amiloride; 3,5-Diamino-6-chloro-N-(piperazin-1-yl)pyrazine-2-carboxamide; Amiloride Piperazine Derivative; N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide piperazine salt; 127628-91-5; N5-Piperazinylamiloride; Piperazine Amiloride Analog
EINECS	Contact for details

Quality Control

Our N(5)-Piperazine-Amiloride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.