Description

2,5-Piperazinedione,3-Hydroxy-3,6-Dimethyl-(9Ci) is a specialized heterocyclic diketopiperazine derivative, a key structural motif in medicinal chemistry and peptide research. This compound matters as a versatile chiral building block and intermediate for the synthesis of complex molecules, including potential pharmaceuticals and bioactive compounds. It is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery, process chemistry, and the development of novel peptidomimetics.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly those with diketopiperazine or constrained peptide backbones.
• Peptidomimetic Research: Used as a scaffold to design and synthesize peptidomimetics, which are molecules that mimic the structure and function of peptides but with enhanced stability and bioavailability.
• Medicinal Chemistry: Acts as a building block for creating compound libraries for high-throughput screening against various biological targets.
• Chemical Biology: Employed in the study of protein-protein interactions and enzyme inhibition due to its rigid, bicyclic structure.
• Process Development: Utilized in route scouting and optimization for the scalable synthesis of complex molecules in pilot plants and commercial manufacturing.
• Academic Research: Fundamental studies in organic synthesis, asymmetric catalysis, and heterocyclic chemistry.

Basic Information

Product Name	2,5-Piperazinedione,3-Hydroxy-3,6-Dimethyl-(9Ci)
CAS No.	127605-72-5
Molecular Formula	C6H10N2O3
Molecular Weight	158.16 g/mol
Synonyms	3-Hydroxy-3,6-dimethylpiperazine-2,5-dione; 3,6-Dimethyl-3-hydroxypiperazine-2,5-dione; (3S,6S)-3,6-Dimethyl-3-hydroxypiperazine-2,5-dione; (3R,6R)-3,6-Dimethyl-3-hydroxypiperazine-2,5-dione; Hydroxy-dimethyl-diketopiperazine; DKP derivative; Chiral diketopiperazine; (9CI) reference compound
EINECS	Contact for details

Quality Control

Our 2,5-Piperazinedione,3-Hydroxy-3,6-Dimethyl-(9Ci) is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee (enantiomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.