Description

Decarestrictine A is a specialized, high-purity secondary metabolite belonging to the class of fungal polyketides, known for its potent biological activity. This compound is of significant interest for advanced research and development in life sciences, particularly for its role as a specific inhibitor of cholesterol biosynthesis. It serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate for pharmaceutical companies, academic institutions, and contract research organizations (CROs) focused on metabolic disease research and novel therapeutic discovery.

Application

• Pharmaceutical Research: As a key reference standard and biochemical tool for studying the inhibition of HMG-CoA reductase and related enzymes in the cholesterol biosynthesis pathway.
• Drug Discovery & Development: Utilized as a lead compound or intermediate in the synthesis and screening of new therapeutic agents targeting hypercholesterolemia and cardiovascular diseases.
• Biochemical Assays: Employed in in vitro enzymatic assays to evaluate potency, mechanism of action, and structure-activity relationships (SAR) of novel inhibitors.
• Academic & Contract Research: Serves as a vital reagent in university laboratories and CROs for fundamental research in metabolism, enzymology, and natural product pharmacology.
• Analytical Method Development: Used as a high-purity calibrant for developing and validating analytical methods (e.g., HPLC, LC-MS) for quality control and pharmacokinetic studies.

Basic Information

Product Name	Decarestrictine A
CAS No.	127393-90-2
Molecular Formula	C21H30O6
Molecular Weight	378.46 g/mol
Synonyms	Decarestrictine A; (3R,4S,5S,6R,8S,10R,12S,14S)-4,6,8,10,12,14-Hexahydroxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,15-dione; L-681,512; Antibiotic L 681512; L 681512; Decarestrictine; Decarestrictin A; 10-Deoxymethynolide
EINECS	Contact for details

Quality Control

Our Decarestrictine A is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications and test results to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the vial to equilibrate to room temperature in a desiccator before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.