Description

1α-Hydroxyprevitamin D2 is a key synthetic intermediate in the production of active vitamin D analogs and related pharmaceutical compounds. This compound matters for its critical role in the biosynthetic pathway, enabling the development of targeted therapies for conditions like osteoporosis and secondary hyperparathyroidism. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) engaged in the synthesis of advanced vitamin D derivatives and metabolic regulators.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of active vitamin D2 metabolites and analogs for clinical research.
• Biochemical Research: Used as a reference standard or starting material in studies investigating vitamin D metabolism, receptor binding, and enzymatic conversion pathways.
• Fine Chemical Synthesis: Serves as a building block for creating novel secosteroids with potential therapeutic applications in bone health and immune modulation.
• Nutraceutical Development: Employed in the research and development of advanced nutritional supplements targeting vitamin D deficiency.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of high-value active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1α-Hydroxyprevitamin D2
CAS No.	127264-18-0
Molecular Formula	C28H44O2
Molecular Weight	412.65 g/mol
Synonyms	1α-Hydroxyergocalciferol precursor; 1α-HO-Previtamin D2; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-1α,3β-diol; 1α-Hydroxyprovitamin D2; Pre-1α-hydroxyvitamin D2; 1α-Hydroxy-9,10-secocholesta-5,7,10(19)-trien-3β-ol
EINECS	Contact for details

Quality Control

Our 1α-Hydroxyprevitamin D2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets rigorous standards suitable for research and pharmaceutical intermediate use. A Certificate of Analysis (COA) detailing specific results for purity, related substances, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to prevent oxidation and degradation. Keep the container in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.