Description

n-(Cyclopropylmethyl)-6,14-Endo-Etheno-7-(3-Carboxy-3-n-Butenyl)Tetrahydronororipavine γ-Lactone is a complex, high-purity synthetic intermediate derived from the oripavine structural framework. This compound matters for its critical role as a key building block in advanced pharmaceutical research and development, particularly in the synthesis of specialized active pharmaceutical ingredients (APIs). It is primarily needed by research institutions, pharmaceutical manufacturers, and fine chemical suppliers engaged in the development of novel therapeutic agents, where precise molecular architecture is paramount.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of potent, specialized pharmaceutical compounds.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new drug candidates.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Fine Chemical Synthesis: Employed in the production of other complex, high-value specialty chemicals requiring the oripavine core structure.

Basic Information

Product Name	n-(Cyclopropylmethyl)-6,14-Endo-Etheno-7-(3-Carboxy-3-n-Butenyl)Tetrahydronororipavine γ-Lactone
CAS No.	127154-03-4
Molecular Formula	C28H31NO5
Molecular Weight	461.55 g/mol
Synonyms	6,14-Endo-etheno-7-(3-carboxy-3-butenyl)-n-(cyclopropylmethyl)-tetrahydronororipavine γ-lactone; 7-(3-Carboxy-3-butenyl)-6,14-endo-etheno-N-(cyclopropylmethyl)-tetrahydronororipavine γ-lactone; Buprenorphine Impurity F; Buprenorphine Related Compound F; Nororipavine γ-lactone derivative; 127154-03-4; Buprenorphine EP Impurity F
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Production adheres to strict quality management systems, and each batch is analyzed to meet precise specifications for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.