Description

11-Glutathionylhepoxilin A3 is a specialized eicosanoid metabolite formed from the conjugation of glutathione to hepoxilin A3. This compound is of significant interest in biochemical research due to its role as a potential mediator in cellular signaling pathways, particularly those related to inflammation and oxidative stress responses. It serves as a critical analytical standard and research reagent for scientists in the fields of lipidomics, pharmacology, and molecular biology.

Application

• Biochemical Research Standard: Used as a high-purity reference standard for the identification and quantification of hepoxilin and glutathione conjugates in complex biological samples via LC-MS or HPLC.
• Lipid Mediator Studies: Essential for investigating the biological activity, metabolism, and signaling pathways of eicosanoid-glutathione adducts in cellular models.
• Pharmacology & Drug Discovery: Employed in target validation and screening assays to study the modulation of inflammatory and redox-related pathways.
• Metabolomics & Biomarker Discovery: A key analyte in profiling oxidative stress and inflammatory metabolites for disease mechanism research.
• Enzyme Activity Assays: Used as a substrate or product in studies involving enzymes like glutathione S-transferases (GSTs) or eicosanoid metabolic enzymes.

Basic Information

Product Name	11-Glutathionylhepoxilin A3
CAS No.	127128-05-6
Molecular Formula	C30H47N3O12S
Molecular Weight	649.78 g/mol
Synonyms	11-Glutathionyl-HXA3; Hepoxilin A3-Glutathione Conjugate; 11-GSH-HXA3; (8R,9S,10S,11R,12Z,14Z)-11-[[(2R)-2-[[(4R)-4-Amino-4-carboxy-1-oxobutyl]amino]-3-[[carboxymethyl]carbamoyl]-1-oxopropyl]thio]-9,10-dihydroxy-8-hydroxy-5,7,12,14-eicosatetraenoic Acid; Glutathionylhepoxilin A3; 11-S-Glutathionylhepoxilin A3
EINECS	Contact for details

Quality Control

Our 11-Glutathionylhepoxilin A3 is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods are validated to meet the rigorous standards expected in pharmaceutical and life science research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.