Description

Piperazine-1,2-Dicarboxylic Acid 1-Benzyl Ester 2-Methyl Ester is a high-value, protected piperazine derivative used as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile chiral intermediate, enabling the construction of complex molecules with precise stereochemistry. It is primarily needed by pharmaceutical R&D and fine chemical manufacturers for developing active pharmaceutical ingredients (APIs), particularly in the areas of central nervous system (CNS) drugs and protease inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used in the design and construction of peptide analogs and protease inhibitor scaffolds.
• Asymmetric Synthesis: Serves as a starting material or auxiliary for catalytic asymmetric reactions to create enantiomerically pure compounds.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic agents.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals, catalysts, and ligands for industrial applications.
• Academic & Contract Research: A valuable reagent for research institutions and CROs (Contract Research Organizations) exploring new synthetic methodologies.

Basic Information

Product Name	Piperazine-1,2-Dicarboxylic Acid 1-Benzyl Ester 2-Methyl Ester
CAS No.	126937-43-7
Molecular Formula	C15H18N2O4
Molecular Weight	290.32 g/mol
Synonyms	1-Benzyl 2-Methyl Piperazine-1,2-dicarboxylate; (2S)-1-[(Benzyloxy)carbonyl]-2-[(methoxy)carbonyl]piperazine; (S)-1-Cbz-2-(COOMe)-piperazine; 1-N-Cbz-2-N-Methoxycarbonylpiperazine; Benzyl (S)-2-(methoxycarbonyl)piperazine-1-carboxylate; Piperazine-1,2-dicarboxylic acid, 1-benzyl ester 2-methyl ester; L-Piperazine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester
EINECS	Contact for details

Quality Control

Our Piperazine-1,2-Dicarboxylic Acid 1-Benzyl Ester 2-Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and fine chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.