Description

Methyl n-4-Boc-n-1-Cbz-2-Piperazinecarboxylate CAS NO 126937-42-6 is a high-purity, protected piperazine derivative widely used as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise molecular architecture, particularly in the development of complex active pharmaceutical ingredients (APIs). It is primarily utilized by the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug candidates, particularly those containing a functionalized piperazine core.
• Peptidomimetics Research: Used to introduce constrained, heterocyclic scaffolds into peptide backbones to enhance metabolic stability and receptor selectivity.
• Combinatorial Chemistry: Serves as a versatile, orthogonally protected building block in solid-phase and parallel synthesis libraries for drug discovery.
• Agrochemical Synthesis: Employed in the development of novel herbicides, fungicides, and insecticides that incorporate nitrogen-containing heterocycles.
• Ligand and Catalyst Development: Useful for constructing chiral ligands and organocatalysts used in asymmetric synthesis.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry and the exploration of new synthetic pathways.

Basic Information

Item	Detail
Product Name	Methyl n-4-Boc-n-1-Cbz-2-Piperazinecarboxylate
CAS No.	126937-42-6
Molecular Formula	C19H26N2O6
Molecular Weight	378.42 g/mol
Synonyms	Methyl 1-[(benzyloxy)carbonyl]-4-(tert-butoxycarbonyl)-2-piperazinecarboxylate; 1-Cbz-4-Boc-piperazine-2-carboxylic acid methyl ester; Methyl 1-Cbz-4-Boc-piperazine-2-carboxylate; 2-Piperazinecarboxylic acid, 1-[(phenylmethoxy)carbonyl]-4-[(1,1-dimethylethoxy)carbonyl]-, methyl ester; Methyl N-Boc-N'-Cbz-piperazine-2-carboxylate; Boc-Cbz-Pip-OMe; (2S)- or (2R)-Methyl 1-Cbz-4-Boc-piperazine-2-carboxylate (for enantiopure forms)
EINECS	Contact for details

Quality Control

Our Methyl n-4-Boc-n-1-Cbz-2-Piperazinecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full specification data are provided and can be tailored to meet specific project requirements, including chiral purity for enantiomerically enriched material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.