Description

n-4-Boc-n-1-Cbz-2-Piperazine Carboxylic Acid is a high-purity, bifunctional protected piperazine derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block and versatile intermediate in the development of complex pharmaceutical molecules. It is primarily required by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for constructing active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Peptidomimetic Chemistry: Used to introduce constrained piperazine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Protecting Group Strategy: The orthogonal Boc and Cbz protecting groups allow for selective deprotection and sequential functionalization in multi-step synthetic routes.
• Ligand and Catalyst Development: Serves as a chiral ligand precursor for asymmetric catalysis and metal complex formation.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes and tool compounds for biological target validation.
• Custom Synthesis: A fundamental starting material for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical synthesis services.

Basic Information

Product Name	n-4-Boc-n-1-Cbz-2-Piperazine Carboxylic Acid
CAS No.	126937-41-5
Molecular Formula	C18H24N2O6
Molecular Weight	364.40 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid; 4-Boc-1-Cbz-piperazine-2-carboxylic acid; 1-Cbz-4-Boc-piperazine-2-carboxylic acid; N-Boc-N'-Cbz-piperazine-2-carboxylic acid; tert-Butyl 2-carboxy-4-[(benzyloxy)carbonyl]piperazine-1-carboxylate; (2S)-1-[(Benzyloxy)carbonyl]-4-[(2-methylpropan-2-yl)oxycarbonyl]piperazine-2-carboxylic acid (for enantiopure form); Boc-Cbz-Pip-OH
EINECS	Contact for details

Quality Control

Our n-4-Boc-n-1-Cbz-2-Piperazine Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and NMR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP starting material applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for enantiopure grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.