Description

(2R,4S)-4-(2H-Tetrazol-5-Ylmethyl)Piperidine-2-Carboxylic Acid is a high-purity chiral piperidine derivative featuring a tetrazole functional group, making it a valuable non-classical bioisostere for carboxylic acids in medicinal chemistry. This compound is critical for pharmaceutical research and development, particularly in the design and synthesis of novel active pharmaceutical ingredients (APIs) targeting cardiovascular and metabolic diseases. It serves as a key chiral building block and intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require precise stereochemistry and high chemical purity for their synthetic routes.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of complex drug candidates, particularly angiotensin II receptor antagonists (sartans) and other cardiovascular agents.
• Medicinal Chemistry Research: Used as a building block in structure-activity relationship (SAR) studies and for creating focused libraries due to its tetrazole moiety, which mimics a carboxylate group.
• API Development: Serves as a precursor in the development and scale-up of new Active Pharmaceutical Ingredients (APIs) requiring high stereochemical purity.
• Bioconjugation & Probe Synthesis: Utilized in the creation of biochemical probes and labeled compounds for pharmacological and diagnostic research.
• Fine Chemical Synthesis: Employed in asymmetric synthesis and the production of other specialized, high-value chiral compounds.

Basic Information

Product Name	(2R,4S)-4-(2H-Tetrazol-5-Ylmethyl)Piperidine-2-Carboxylic Acid
CAS No.	125546-04-5
Molecular Formula	C9H15N5O2
Molecular Weight	225.25 g/mol
Synonyms	(2R,4S)-4-(1H-Tetrazol-5-ylmethyl)piperidine-2-carboxylic acid; (2R,4S)-4-((2H-Tetrazol-5-yl)methyl)piperidine-2-carboxylic acid; 4-(1H-Tetrazol-5-ylmethyl)-2-piperidinecarboxylic acid, (2R,4S)-; (2R,4S)-4-(Tetrazol-5-ylmethyl)piperidine-2-carboxylic acid; 125546-04-5; UNII-7Q6K1P8B4I; SCHEMBL218062; ZINC000253909991
EINECS	Contact for details

Quality Control

Our (2R,4S)-4-(2H-Tetrazol-5-Ylmethyl)Piperidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure compliance with stringent specifications for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and cGMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.