Description

(3S,4R)-(-)-4-(4'-Fluorophenyl)3-Hydroxymethyl)-Piperidine CAS NO 125224-43-3 is a high-purity chiral piperidine derivative, a critical building block in modern asymmetric synthesis. Its defined stereochemistry and functional groups make it an essential intermediate for developing enantiomerically pure active pharmaceutical ingredients (APIs). This compound is primarily sought by pharmaceutical R&D and fine chemical manufacturers for the synthesis of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of enantiomerically pure Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Used as a building block for constructing complex molecules with defined stereocenters in medicinal chemistry.
• Neurological & CNS Drug Research: Serves as a precursor in the development of potential therapeutics targeting neurological disorders.
• Catalyst & Ligand Development: Employed in the research and preparation of chiral catalysts and ligands for stereoselective transformations.
• Academic & Industrial R&D: Utilized in research laboratories for method development and exploring new synthetic pathways.
• Fine Chemical Production: Integral to the multi-step synthesis of high-value specialty chemicals and advanced materials.

Basic Information

Product Name	(3S,4R)-(-)-4-(4'-Fluorophenyl)-3-(hydroxymethyl)piperidine
CAS No.	125224-43-3
Molecular Formula	C12H16FNO
Molecular Weight	209.26 g/mol
Synonyms	(3S,4R)-4-(4-Fluorophenyl)-3-(hydroxymethyl)piperidine; (-)-4-(4'-Fluorophenyl)-3-(hydroxymethyl)piperidine; (3S,4R)-(-)-4-(4-Fluorophenyl)-3-piperidinemethanol; 4-(4-Fluorophenyl)-3-(hydroxymethyl)piperidine (enantiomer); (3S,4R)-4-(4-Fluorophenyl)-3-piperidinemethanol; (3S,4R)-3-(Hydroxymethyl)-4-(4-fluorophenyl)piperidine; (3S,4R)-4-(4-Fluorophenyl)piperidine-3-methanol
EINECS	Contact for details

Quality Control

Our (3S,4R)-(-)-4-(4'-Fluorophenyl)-3-(hydroxymethyl)piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and fine chemical synthesis. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.