Description

1-Palmitoyl-2-(15-Hydroxy-5,8,11,13-Eicosatetraenoyl)-Glycero-3-Phosphocholine is a specialized, high-purity phospholipid derivative, also known as 15-HETE-PC, which serves as a critical bioactive lipid mediator and research standard. This compound is essential for studying cellular signaling pathways, inflammation, and oxidative stress responses due to its role as a precursor for potent eicosanoids. It is primarily utilized by pharmaceutical researchers, academic institutions, and diagnostic developers focused on lipidomics, drug discovery, and the development of analytical reference materials.

Application

• Biomedical Research Standard: Used as a high-purity reference standard in mass spectrometry (LC-MS/MS) and HPLC for the quantification of oxidized phospholipids in biological samples.
• Cell Signaling Studies: Investigated as a precursor for bioactive eicosanoids to elucidate mechanisms in inflammation, apoptosis, and oxidative stress pathways.
• Lipidomics and Metabolomics: A key component in lipidomic profiling kits and panels for studying complex lipid networks in disease states.
• Pharmaceutical Development: Employed in target validation and screening assays for novel anti-inflammatory and cardioprotective drug candidates.
• Diagnostic Reagent Manufacturing: Incorporated into the development of ELISA kits and other immunoassays for detecting specific lipid oxidation biomarkers.
• Biochemical Tool Compound: Used to modulate specific enzymatic activities (e.g., phospholipase A2) in controlled *in vitro* experiments.

Basic Information

Product Name	1-Palmitoyl-2-(15-Hydroxy-5,8,11,13-Eicosatetraenoyl)-Glycero-3-Phosphocholine
CAS No.	125139-36-8
Molecular Formula	C45H82NO9P
Molecular Weight	812.11 g/mol
Synonyms	15-HETE-PC; 1-Palmitoyl-2-15-HETE-sn-glycero-3-phosphocholine; 15-Hydroxyeicosatetraenoic Acid-Phosphatidylcholine; PC(16:0/15-HETE); Oxidized Phosphatidylcholine; 15(S)-HETE-PC; 1-Hexadecanoyl-2-(15-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine
EINECS	Contact for details

Quality Control

Our 1-Palmitoyl-2-(15-Hydroxy-5,8,11,13-Eicosatetraenoyl)-Glycero-3-Phosphocholine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant guidelines for research-grade biochemicals, and stability data is maintained to support product integrity.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). The product is hygroscopic (moisture-sensitive) and easily oxidized; allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake and degradation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Solubility	Soluble in chloroform, ethanol; slightly soluble in aqueous buffer
Heavy Metals	< 10 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.